The inherent difference in nucleophilicity between alkyl alcohols and free hemiacetals is capitalized upon in a new approach to chemoselective glycosylation. The strategy employs a controlled dehydrative coupling reaction for the rapid assembly of complex oligosaccharides and obviates the need for the extensive protective group and anomeric leaving group differentiation that is traditionally required.
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| http://dx.doi.org/10.1002/1521-3773(20010119)40:2<414::AID-ANIE414>3.0.CO;2-6 | DOI Listing |
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