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A Synthetic Pore-Mediated Transmembrane Transport of Glutamic Acid. | LitMetric

A Synthetic Pore-Mediated Transmembrane Transport of Glutamic Acid.

Angew Chem Int Ed Engl

Departments of Chemistry and Molecular Biology, and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) Fax: (+1) 858-784-2798.

Published: July 2001

Transported to the other side: Cyclic D,L-α-peptides self-assemble in lipid bilayers into transmembrane ion channels that may allow efficient transport of glutamic acid. The molecular transport is size/shape selective, as evidenced by the high transport rates observed with cyclodecapeptide-based transmembrane pores but not with the smaller cyclooctapeptide analogue.

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http://dx.doi.org/10.1002/1521-3773(20010702)40:13<2503::AID-ANIE2503>3.0.CO;2-EDOI Listing

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