Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewis Structure.

Particularly selective methods are required for the synthesis of arabino sialyl Lewis glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis glycopeptide 1, which contains the Gly  -Asp  sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewis to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential.