Olefinic analogues of effective peptide-based catalysts for the kinetic resolution of functionalized racemic secondary alcohols have been synthesized. The isosteric replacement of the peptide amide bond in 1 with an (E)-alkene to form 2 has enabled the evaluation of the kinetic role of particular amides within these catalysts.
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| http://dx.doi.org/10.1002/1521-3773(20010803)40:15<2824::AID-ANIE2824>3.0.CO;2-J | DOI Listing |
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