The Vancomycin Group of Antibiotics and the Fight against Resistant Bacteria.

Angew Chem Int Ed Engl

Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW (UK), Fax: (+44) 1223-336913.

Published: May 1999

A last line of defence against "superbugs" are the vancomycin group antibiotics. This review describes the determination of their mode of action, and a mechanism of resistance to them. Remarkably, this mechanism of resistance can be overcome without directly modifying the binding site of the antibiotics for the cell-wall precursors of pathogenic bacteria.

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http://dx.doi.org/10.1002/(SICI)1521-3773(19990503)38:9<1172::AID-ANIE1172>3.0.CO;2-CDOI Listing

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