Simple monitoring of lipase- and transition metal catalyzed asymmetric esterifications [Eq. (1)] and opening of epoxides [Eq. (2)] can be achieved by IR thermography. Thus, a new method is available for screening of enantioselectivity in catalytic reactions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/(SICI)1521-3773(19981016)37:19<2647::AID-ANIE2647>3.0.CO;2-I | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biocatalytic Generation of Trifluoromethyl Radicals by Nonheme Iron Enzymes for Enantioselective Alkene Difunctionalization.
J Am Chem Soc
December 2024
Department of Chemistry, Johns Hopkins University; Baltimore, Maryland 21218, United States.
The trifluoromethyl (-CF) group represents a highly prevalent functionality in pharmaceuticals. Over the past few decades, significant advances have been made in the development of synthetic methods for trifluoromethylation. In contrast, there are currently no metalloenzymes known to catalyze the formation of C(sp)-CF bonds.
View Article and Find Full Text PDFExpanding the scope of copper artificial metalloenzymes: A potential fluorinase?
J Inorg Biochem
February 2025
EaStCHEM School of Chemistry, Joseph Black Building, Kings Buildings, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, UK. Electronic address:
Biocatalysts for fluorination are rare, and thus of great interest for artificial enzyme design. Biohybrid catalysts including Cu-based DNAzymes and dinucleotide catalysts can catalyse enantioselective electrophilic fluorination of β-ketoesters. Here we report the investigation of Cu-based artificial metalloenzymes as catalysts for electrophilic fluorination reactions.
View Article and Find Full Text PDFTargeted Chiral Metabolomics of D-Amino Acids: Their Emerging Role as Potential Biomarkers in Neurological Diseases with a Focus on Their Liquid Chromatography-Mass Spectrometry Analysis upon Chiral Derivatization.
Int J Mol Sci
November 2024
Research Group Experimental Pharmacology (EFAR), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.
Article Synopsis
- Chiral metabolomics is a growing area in neuroscience that focuses on D-amino acids as potential biomarkers for neurological diseases, utilizing advanced analytical techniques like liquid chromatography-mass spectrometry (LC-MS).
- The review highlights the importance of D-amino acids in disease pathology, particularly their influence on neurotransmission, and discusses the need for sensitive methods due to their low concentration in biological samples.
- Recent advancements in chiral derivatization and LC-MS/MS techniques have improved the detection and quantification of D-amino acids, enhancing our understanding of their role in neurological disorders and drug interactions in the brain.
Multiomics-guided mining and characterization of epoxide hydrolase involved in camptothecin biosynthesis from Camptotheca acuminata.
Bioorg Chem
December 2024
College of Science, Sichuan Agricultural University, Ya'an 625104, China; Featured Medicinal Plants Sharing and Service Platform of Sichuan Province, Ya'an 625104, China. Electronic address:
Article Synopsis
- The hydrolysis step of 2,7-epoxy is crucial for the production of camptothecin (CPT), a compound with potent cancer-fighting properties, yet the specific genes involved have not been previously identified.
- This study identifies three genes (CaEH1-CaEH3) responsible for the epoxide hydrolase activity in Camptotheca acuminata and highlights their ability to catalyze the opening of various oxirane rings.
- Functional tests show that these genes are actively involved in CPT biosynthesis, are expressed in all plant tissues with a concentration in leaves, and suggest a convergence in their evolutionary development from different ancestral genes.
Enantioseparation, Absolute Configuration, and Enantioselective Bioactivity Mechanism of the Chiral Fungicide Nuarimol.
J Agric Food Chem
November 2024
Department of Pesticide Science, College of Plant Protection, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing 210095, China.
In this study, the nuarimol enantiomers were successfully baseline separated with Rs 1.70 by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The absolute configurations of the nuarimol enantiomers were confirmed as -(+)-nuarimol and -(-)-nuarimol.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!