Opposite Orientation of Backbone Inclination in Pyranosyl-RNA and Homo-DNA Correlates with Opposite Directionality of Duplex Properties.

Angew Chem Int Ed Engl

Laboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule Universitätsstrasse 16, CH-8092 Zürich (Switzerland), Fax: (+41) 1-632-1043 (and) The Skaggs Institute for Chemical Biology at The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037 (USA).

Published: March 1999

Backbone inclination is a parameter which can be used for the classification of the structure type of oligonucleotide duplexes. Its significance for the interpretation of the sequence dependence of duplex stability is illustrated based on examples of the p-RNA and homo-DNA series.

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http://dx.doi.org/10.1002/(SICI)1521-3773(19990301)38:5<680::AID-ANIE680>3.0.CO;2-CDOI Listing

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