The evaluation of estuarine wetland ecosystem health (EWEH) is vital and difficult due to complex influencing factors and their spatial heterogeneities. An EWEH evaluation model was established in this study on the basis of the typical features of estuarine wetland ecosystems with focus on spatial heterogeneity. The index system comprises external factors, internal factors, and ecological state, and covers all aspects of the natural and anthropogenic factors, with each index possessing its own spatial heterogeneity. The Yellow River Delta, a typical estuarine wetland in China, was selected as the study area to demonstrate the model. Results indicated that the present EWEH in the entire study area was in good status with distinct spatial heterogeneity. Ecosystem productivity, seawater intrusion, human interference, and Yellow River input were the most relevant indexes of EWEH. The temporal variations of EWEH fluctuated from 1987 to 2016. The decrease in the Yellow River input and the increase in human activity intensity deteriorated EWEH, whereas the alongshore embankment and nature reserve construction improved EWEH in certain parts. The influence of natural factors continuously decreased, and human activity became the main driving factor of the EWEH spatial variation. Our model was proven to possess comprehensive reflections of estuarine wetland ecological characteristics, full exhibitions of spatial heterogeneity, and high applicability; therefore, it can be widely used to evaluate EWEH in different areas.
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http://dx.doi.org/10.1016/j.scitotenv.2018.04.085 | DOI Listing |
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA; NYU, New York City, NY, USA.
Background: Astrocytes, a major glial cell in the central nervous system (CNS), can become reactive in response to inflammation or injury, and release toxic factors that kill specific subtypes of neurons. Over the past several decades, many groups report that reactive astrocytes are present in the brains of patients with Alzheimer's disease, as well as several other neurodegenerative diseases. In addition, reactive astrocyte sub-types most associated with these diseases are now reported to be present during CNS cancers of several types.
View Article and Find Full Text PDFBrief Bioinform
November 2024
School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240 Shanghai, China.
Identifying spatial domains is critical for understanding breast cancer tissue heterogeneity and providing insights into tumor progression. However, dropout events introduces computational challenges and the lack of transparency in methods such as graph neural networks limits their interpretability. This study aimed to decipher disease progression-related spatial domains in breast cancer spatial transcriptomics by developing the three graph regularized non-negative matrix factorization (TGR-NMF).
View Article and Find Full Text PDFParasit Vectors
January 2025
National Centre for Epidemiology and Population Health, Australian National University, 62 Mills Road, Canberra, 2601, ACT, Australia.
Background: Elimination of lymphatic filariasis (LF) is a World Health Organization goal, with several countries at or near prevalence thresholds. Where LF cases remain after mass drug administration, they tend to be spatially clustered, with an overdispersed individual worm burden. Both individual and spatial heterogeneities can cause aggregation of infection; however, few studies have investigated the drivers of heterogeneity and implications for disease elimination.
View Article and Find Full Text PDFSci Rep
January 2025
Marine Biotechnology Fish Nutrition and Health Division, ICAR-Central Marine Fisheries Research Institute, Ernakulam North P O, Kochi, Kerala, 682018, India.
The Indian scad, Decapterus russelli is one of the most exploited pelagic resources of India. Population genetic analyses using mitochondrial and nuclear markers indicated a lack of genetic structuring among populations from Indian waters. As this species is highly migratory, it is also important to establish the environmental influence on its population structure.
View Article and Find Full Text PDFNature
January 2025
The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the prefrontal cortex and the primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence.
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