A new ruthenium-catalyzed hydrodemethoxylation of ortho-methoxy-benzamides and -naphthamides involving amide-directed C-OMe bond activation and hydride reduction is disclosed. The reaction is general, proceeding under RuH(CO)(PPh) catalysis using either triethylsilane (EtSiH) or diisobutylaluminum hydride (DIBAL-H) as the reductant. The corresponding C-N hydrodeamination reaction is also briefly reported.
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Amide-Directed Ru-Catalyzed Hydrodemethoxylation of ortho-Methoxy-Benzamides and -Naphthamides: A D oM Reaction Counterpart.
Org Lett
May 2018
Department of Chemistry , Queen's University, 90 Bader Lane , Kingston , ON K7L 3N6 , Canada.
A new ruthenium-catalyzed hydrodemethoxylation of ortho-methoxy-benzamides and -naphthamides involving amide-directed C-OMe bond activation and hydride reduction is disclosed. The reaction is general, proceeding under RuH(CO)(PPh) catalysis using either triethylsilane (EtSiH) or diisobutylaluminum hydride (DIBAL-H) as the reductant. The corresponding C-N hydrodeamination reaction is also briefly reported.
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