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Results of Concurrent Patch Testing of Brazilian and Chinese Propolis.
Contact Dermatitis
December 2024
Dermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Background: In Amsterdam, a steep increase in positive reactions to propolis in the European baseline series was observed from 2.8% in 2020 to 16.4% in 2023.
View Article and Find Full Text PDFEnhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification.
Environ Toxicol Pharmacol
December 2024
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Lower Kent Ridge Road, 4 Science Drive 2, Singapore 117544. Electronic address:
The metabolic conversion of aromatic amines to N-acetylated forms in skin and keratinocytes depends on N-acetyltransferase-1 (NAT1). Common hair color ingredient such as para-phenylenediamine (PPD) causes allergic contact dermatitis. We explored how different electronic substituents on PPD aided NAT1 enzyme biotransform oxidative arylamine (AA) compounds G1-G13 by N-acetylation, NAT-1 activity assays, metabolism, and in vitro clearance investigations in human keratinocytes, while identifying NAT-1 protein levels by Western blot and qRT-PCR.
View Article and Find Full Text PDFWatch Out! Potential Allergic Contact Dermatitis to Acrylates in a Smart Watch.
Contact Dermatitis
December 2024
Aneurin Bevan University Health Board, St. Woolos Hospital, Newport, UK.
Contact Allergy to Methacrylate Containing Nail Products: Lack of Impact of EU Legislation. An Audit on Behalf of the European Environmental Contact Dermatitis Research Group (EECDRG).
Contact Dermatitis
December 2024
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Background: There is a current fashion for the use of methacrylate-containing nail cosmetics that can induce allergic contact dermatitis. European Union (EU) legislation was introduced in 2021 that had the aim of preventing its development.
Objectives: To assess prevalence and exposures causing contact allergy to 2-hydroxyethyl methacrylate (HEMA) prior to and following implementation of the legislation.
Old Players, New Tricks: Dicaprylyl Maleate in an Unlabeled Topical Medical Device as the Cause of Severe Allergic Contact Dermatitis in a Child.
Contact Dermatitis
December 2024
Department of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, INFLA-MED Centre of Excellence, University of Antwerp, Antwerp, Belgium.
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