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http://dx.doi.org/10.1111/jsap.12852 | DOI Listing |
Objective: To evaluate the clinical benefit and adverse events following outpatient intravenous (IV) ketamine-lidocaine (KL) infusions for palliation of cancer pain in dogs and cats.
Methods: Medical records from 15 years (2008 to 2023) were searched and data reviewed retrospectively. Animals were prescribed ketamine (0.
Given the limited data on the real-life therapeutic use of feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3) inhibitors in Italy, we surveyed investigators at 59 Italian hematology centers to gain insight into the proportion of acute myeloid leukemia (AML) patients receiving FLT3 inhibitors and we collected data on the efficacy and safety of these agents. The survey results showed that in the real-life setting the response rate of the 3/7 + midostaurin regimen in newly diagnosed FLT3-mutated AML and of gilteritinib in the relapsed/refractory AML were comparable to that reported in the registrative clinical trials. The 3/7 + midostaurin treatment resulted in a 63% of complete remission (CR) rates and gilteritinib in a 44% of CR rates.
View Article and Find Full Text PDFTrends Hear
November 2024
Department of Medical Physics and Acoustics, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Most neural models produce a spiking output and often represent the stochastic nature of the spike generation process via a stochastic output. Nonspiking neural models, on the other hand, predict the probability of a spike occurring in response to a stimulus. We propose a nonspiking model for an electrically stimulated auditory nerve fiber, which not only predicts the total probability of a spike occurring in response to a biphasic pulse but also the distribution of the spike time.
View Article and Find Full Text PDFJ Vet Intern Med
December 2024
Division of General and Interventional Radiology and Neuroradiology, Department of Radiology, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Background: Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely used in human medicine, can now be applied in veterinary medicine because of the availability of brain atlases.
Objectives: This study aimed to develop an automatic volumetry method, translate the outcomes into the assessment of temporal lobe volumes in dogs with idiopathic epilepsy, and correlate the results with the electroencephalography (EEG) data of epileptiform discharges (EDs).
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biochemistry & Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Feline chronic gingivostomatitis (FCGS) is a painful and severe inflammatory mucosal disease in cats that presents significant challenges in treatment. This case study describes a novel approach for a cat with FCGS that was unresponsive to antibiotics, non-steroidal anti-inflammatory drugs, and dental extraction. The cat exhibited rapid improvement after undergoing oral indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (aPDT); however, treatment was discontinued due to an episode of anaphylaxis.
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