A tandem reaction of heterocyclic ketene aminals and 1,2-diaza-1,3-dienes was developed for the expedient synthesis of pyrimidopyrrolopyridazine derivatives. This process involved an intramolecular conjugate addition followed by CuCl-catalyzed hydrazone formation.
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| http://dx.doi.org/10.1021/acs.orglett.8b01094 | DOI Listing |
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