We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of hematopoiesis has significant implications for targeting tissue eosinophils.
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| http://dx.doi.org/10.1016/j.jaci.2018.02.054 | DOI Listing |
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