AI Article Synopsis
- The study explored self-assemblies in bile salt/phospholipid blends using asymmetrical flow field-flow fractionation (AF4) and multi-angle laser light scattering (MALLS) to identify different colloidal structures.
- The blends, made with sodium taurocholate or sodium glycodeoxycholate and specific phospholipids, were analyzed at various concentrations mimicking human intestinal conditions, with the inclusion of the drug Celecoxib to examine its influence.
- Results indicated that at higher bile salt concentrations, three distinct particle types formed, and Celecoxib could be encapsulated within these structures, even leading to an additional vesicular phase at low concentrations.
Article Abstract
Colloidal phases (self-assemblies) in aqueous dispersions of selected binary bile salt/phospholipid blends were studied utilizing the combined analytical approach of asymmetrical flow field-flow fractionation (AF4) and multi-angle laser light scattering (MALLS) in order to resolve the co-existence of different colloidal assemblies. The binary blends were prepared by freeze-drying from tert-butanol/water co-solvent solutions. The blends contained one of two bile salts (sodium taurocholate (TC) or sodium glycodeoxycholate (GDX)) and a mono- or di-acyl phospholipid (lyso-phosphatidylcholine (L-PC) and phosphatidylcholine (PC), respectively). Bile salt and phospholipid (PL) concentrations and their respective ratios were varied systematically within the physiological range found in human intestinal fluids. Furthermore, the BCS class II drug Celecoxib was incorporated in selected blends to assess its potential impact on colloidal phases. To further investigate the smallest self-assemblies observed in AF4/MALLS analysis, dispersions of TC and GDX, respectively, were prepared and analyzed by dynamic light scattering (DLS). AF4/MALLS analysis revealed that binary bile-salt/phospholipid blends form three distinct particle fractions, when the concentration of bile-salt was sufficiently high (≥3.5 mM). Those fractions were assumed to be very small pure bile-salt dimeric/oligomeric self-assemblies (Ø ≈ 2-3 nm), mid-sized mixed micelles (Ø ≈ 10-50 nm) and large liposomes/aggregates (Ø ≈ 150-280 nm). If present, Celecoxib was found solubilized within the structures, but at the lowest TC concentration triggered the formation of an additional (vesicular) phase.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejps.2018.04.031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydrogen Bonding-Driven Adaptive Coacervates as Protocells.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Coacervation based on liquid-liquid phase separation (LLPS) has been widely used for the preparation of artificial protocells and to mimic the dynamic organization of membrane-free organelles. Most complex synthetic coacervates are formed through electrostatic interactions but cannot withstand high ionic strength conditions (>0.1 M).
View Article and Find Full Text PDFP2-NaMnNiCoO stabilized by optimal active facets for sodium-ion batteries.
J Colloid Interface Sci
January 2025
MOE Key Laboratory for UV Light-Emitting Materials and Technology, Department of Physics, Northeast Normal University, Changchun, Jilin 130024, PR China; Faculty of Chemistry, Northeast Normal University, Changchun, Jilin 130024, PR China. Electronic address:
Considering factors such as crustal reserves, atomic mass, redox potential and energy density, sodium-ion batteries (SIBs) are regarded as the most promising alternative to lithium-ion batteries (LIBs). Transition metal-based layered oxides, especially typical NaMnO, stand out among cathode materials due to their low cost and high energy density. However, NaMnO cathodes face several challenges, including Jahn-Teller distortion, manganese dissolution, structural collapse, irreversible phase transition and significant capacity loss.
View Article and Find Full Text PDFActivity waves in condensed excitable phases of Quincke rollers.
Soft Matter
January 2025
Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, P. R. China.
Traveling waves are universal in excitable systems; yet, the microscopic dynamics of wave propagation is inaccessible in conventional excitable systems. Here, we show that active colloids of Quincke rollers driven by a periodic electric field can form condensed excitable phases. Distinct from existing excitable media, condensed excitable colloids can be tuned reversibly between active liquids and active crystals in which two distinct waves can be excited, respectively.
View Article and Find Full Text PDFDevelopment of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation.
Int J Nanomedicine
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.
Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.
Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 3 factorial design.
Design and synthesis of autogenous growth NiFe bimetallic phosphide catalysts on a nickel iron foam-like substrate for efficient overall water splitting.
J Colloid Interface Sci
January 2025
Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province, School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, PR China. Electronic address:
Article Synopsis
- The study focuses on creating effective and affordable electrocatalysts for water electrolysis, vital for improving technology in this area.
- The authors developed a novel catalyst by anchoring carbonyl iron powder in nickel foam, leading to enhanced surface area and efficient ion movement.
- The catalyst exhibits high activity due to a dynamic interaction between different nickel and iron phases, significantly boosting its performance in the oxygen evolution reaction.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!