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Fetal-to-Neonatal Transition of an Infant with Transposition of the Great Arteries and Intact Ventricular Septum: A Case Report.
Biomed Hub
December 2024
Division of Paediatric Cardiology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre (LUMC), Leiden, The Netherlands.
Introduction: Transposition of the great arteries (TGA), especially with intact ventricular septum (TGA-IVS), presents unique challenges during fetal-to-neonatal transition, which can contribute to developing persistent pulmonary hypertension of the newborn (PPHN).
Case Presentation: A male newborn with TGA-IVS, delivered via caesarean section, presented with hypoxemia and tachycardia immediately after birth (preductal SpO: 50-60%, post-ductal SpO: 70-75%). Echocardiography revealed a floppy interatrial septum and two interatrial connections with bidirectional shunting.
Clozapine treatment of a Japanese patient during pregnancy: Effect on fetal heart rate.
Neuropsychopharmacol Rep
December 2024
Department of Psychiatry, Japanese Red Cross Narita Hospital, Narita-shi, Chiba, Japan.
Article Synopsis
- A case study of a 29-year-old Japanese woman with schizophrenia on clozapine during pregnancy showed no complications until a late incident of premature rupture of membranes, which led to an emergency cesarean section.
- The study indicates that clozapine and its metabolite norclozapine were transferred to the fetus and may have impacted fetal heart rate; it advises careful monitoring of clozapine levels and fetal health during pregnancy for better outcomes.
Surgical outcomes of external double needle puncture epiglottopexy in severe laryngomalacia patients with high-risk comorbidities.
Int J Pediatr Otorhinolaryngol
August 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:
Article Synopsis
- The study investigates the surgical outcomes of epiglottopexy using external double needle puncture in infants under 12 months with severe laryngomalacia (LM) and serious comorbidities.
- Out of 32 patients, 68.7% had successful outcomes, while the remaining faced complications requiring tracheostomies or ventilation support.
- The research concludes that this surgical method is generally effective, but factors like low gestational age may increase the risk of failure; careful pre- and post-surgery monitoring of related conditions is essential for better results.
Congenital eyelid imbrication syndrome: A rare occurrence in Pakistan.
J Pak Med Assoc
June 2024
Isra Postgraduate Institute of Ophthalmology, Karachi, Pakistan.
Article Synopsis
- * This overlapping results in the upper eyelid spontaneously turning outward (eversion) over time.
- * In the case studied, the patient showed normal eye structures, and no treatment was necessary as the condition resolved itself within two weeks.
[The importance of early recognition of Prader-Willi syndrome].
Ned Tijdschr Geneeskd
May 2024
Radboudumc/Amalia Kinderziekenhuis, afd. Kindergeneeskunde/Expertisecentrum Prader-Willi-syndroom, Nijmegen.
Due to its rare nature and subtle dysmorphisms, Prader-Willi syndrome can be challenging to recognize and diagnose in the neonatal period. Feeding difficulties and hypotonia ('floppy infant') are the most striking characteristics. Prader-Willi syndrome requires specific follow-up and treatment, emphasizing the importance of early recognition.
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