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Analysis of human neutrophils from nasal polyps by single-cell RNA sequencing reveals roles of neutrophils in chronic rhinosinusitis.
J Allergy Clin Immunol
November 2024
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 (T2) inflammation. Recent studies, including our own, suggest that neutrophils are also elevated in T2 nasal polyps (NP) and that elevated neutrophils display an activated phenotype. However, the actual roles of neutrophils in NP pathogenesis in T2 CRSwNP are still largely unclear.
View Article and Find Full Text PDFOptimizing Siglec-8-Directed Immunotherapy for Eosinophilic and Mast Cell Disorders.
Cancers (Basel)
October 2024
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Current treatments for eosinophilic and mast cell disorders are often ineffective. One promising target to improve outcomes is sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8). As limitations, there are few Siglec-8 monoclonal antibodies (mAbs) available to date, and Siglec-8-directed treatments have so far primarily focused on unconjugated mAbs, which may be inadequate, especially against mast cells.
View Article and Find Full Text PDFIncreased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps.
JCI Insight
September 2024
Department of Otolaryngology.
Article Synopsis
- * Researchers found that NP B cells expressing the extrafollicular marker EBI2 had a higher propensity for autoantibody production and that NP ASCs were more common than those in tonsils.
- * Analysis showed significant differences in the composition and molecular characteristics of B cells, indicating that NP EBI2+ ASCs produce more total and anti-dsDNA IgG and exhibit traits of mature plasma cells.
Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the human esophagus.
Glycobiology
August 2024
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, United States.
Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells, which are effectors in allergic disorders including eosinophilic esophagitis. Inhibition occurs when Siglec-8 is crosslinked by multivalent Siglec ligands in target tissues.
View Article and Find Full Text PDFSingle cell RNA sequencing of human eosinophils from nasal polyps reveals eosinophil heterogeneity in chronic rhinosinusitis tissue.
J Allergy Clin Immunol
October 2024
Department of Medicine, Division of Allergy and Immunology, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) involves complex inflammation, and the specific functions of eosinophils in this condition are not well understood.
- Researchers used single-cell RNA sequencing to analyze eosinophils in nasal polyp tissue from patients with CRSwNP, comparing them to control samples.
- The study identified a diverse range of eosinophil subtypes in nasal polyps, with certain genes related to inflammation and cell growth being significantly upregulated, suggesting their key role in CRSwNP pathology.
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