A PHP Error was encountered
Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_session9g41ro5o61jn6v2ddc99m14cmeun13kv): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Effects of Post-Weaning Chronic Stress on Nociception, Spinal Cord μ-Opioid, and α2-Adrenergic Receptors Expression in Rats and Their Offspring.
J Mol Neurosci
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Published: April 2018
Stressful situations can change biological process in human and animal, and some of these changes may transfer to the next generations. We used a communication box to induce chronic electrical foot-shock stress in rats. Tail flick latency and formalin test were done to determine the level of pain sensation. Real-time RT-PCR was used to measure the level of spinal cord μ-opioid (MOR) and α2-adrenergic receptors (α2-AR) mRNA. We demonstrate that chronic stress can change nociception and leads to hyperalgesia. Moreover, spinal cord MOR mRNA level decreased following chronic stress. We did not observe any significant changes in the level of spinal cord α2-AR mRNA between stressed and non-stressed rats. In addition, non-stressed sons of stressed mothers showed hyperalgesia compared to the control group. They showed lesser level of MOR mRNA level in comparison to the control rats. Furthermore, stressed sons of stressed mothers illustrated more hyperalgesia than the other stressed groups. We indicate that chronic stress can reduce spinal cord MOR mRNA level and lead to hyperalgesia. Additionally, these changes can transfer to offspring.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12031-018-1068-4 | DOI Listing |
Similar Publications
Coherence-Based Graph Convolution Network to Assess Brain Reorganization in Spinal Cord Injury Patients.
Int J Neural Syst
March 2025
Institute for Neural Computation and Institute of Engineering in Medicine, University of California San Diego, CA 92093-0559, USA.
Motor imagery (MI) engages a broad network of brain regions to imagine a specific action. Investigating the mechanism of brain network reorganization during MI after spinal cord injury (SCI) is crucial because it reflects overall brain activity. Using electroencephalogram (EEG) data from SCI patients, we conducted EEG-based coherence analysis to examine different brain network reorganizations across different frequency bands, from resting to MI.
View Article and Find Full Text PDFPhotobiomodulation therapy facilitates transplantation of dental pulp stem cells for spinal cord injury.
Photodiagnosis Photodyn Ther
March 2025
Department of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Present address: Department of Physiology, University of California, San Francisco, CA, 94107, USA. Electronic address:
Background: While dental pulp stem cells (DPSCs) show therapeutic potential for spinal cord injury (SCI), post-traumatic oxidative stress and mitochondrial dysfunction critically compromise grafted cell survival. Photobiomodulation therapy (PBMT) is a noninvasive approach that may enhance regenerative efficacy. This study investigates whether PBMT improves the survival and neural differentiation of transplanted DPSCs in SCI models.
View Article and Find Full Text PDFMALAT1 promotes microglia activation and neuronal apoptosis through via the miR-124-3p/ SGK1 axis mediating experimental autoimmune encephalomyelitis disease progression in mice.
Int Immunopharmacol
March 2025
Department of Neurology, Women and Children's Hospital Affiliated to Ningbo University, Ningbo 315012, China. Electronic address:
Multiple sclerosis (MS) significantly impairs quality of life due to its high disability rate. Recent research indicates that the long non-coding RNA Malat1 is specifically upregulated in MS and is critically involved in mediating neuroinflammatory responses and microglial activation. This study explores the function and mechanism of the Malat1/miR-124-3p/Sgk1 pathway in MS and microglia activation.
View Article and Find Full Text PDFPatients' perspectives of receiving an early vocational rehabilitation following major traumatic injury.
Disabil Rehabil
March 2025
Monash-Epworth Rehabilitation Research Centre, School of Psychological Sciences, Monash University, Clayton, Australia.
Purpose: Return to work (RTW) after a major traumatic injury (MTI; traumatic brain injury, spinal cord injury, multi-trauma orthopaedic injury) is an important rehabilitation outcome. This study aimed to explore the experience of early vocational rehabilitation (EVR) after MTI, and RTW barriers/facilitators.
Methods: Adopting a qualitative design, 24 people with MTI were interviewed about participating in the Early Intervention Vocational Rehabilitation Service (EIVRS).
Neurotransmitters' white matter mapping unveils the neurochemical fingerprints of stroke.
Nat Commun
March 2025
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, France.
Distinctive patterns of brain neurotransmission frame determinant circuits for behavior. Understanding the relationship between their damage and the cognitive impairment provoked by brain lesions could provide insights into the pathophysiology and therapeutics of disabling disorders, like stroke. Yet, the challenges of neurotransmitter circuits mapping in vivo have hampered this investigation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.