Background: Metabolic syndrome (MS) is considered one of the major worldwide epidemics. It accounts for billions of cardiovascular disease events and deaths. Till now, major basics of MS are not fully clarified. Peroxisome Proliferator-Activated Receptor-α (PPARα) displays a ligand-activated transcription factor. It is involved in the regulation of many metabolic processes including inflammation, lipid, and glucose metabolism. Therefore, this study investigated the leucocytic expression of PPARα in a metabolic patient in comparison to healthy controls.
Methods: 100 subjects with MS were recruited, in addition to 100 subjects without any obvious metabolic disorders as healthy controls. Expression of PPARα and CD 36 were analyzed on different leucocytic populations using optimized flow-cytometric analysis. Correlations of the expression of both indexes with different clinical and laboratory parameters were analyzed.
Results: The eosinophilic expression of PPARα was found to be lower in subjects with MS in comparison to the healthy controls (p value 0.001). Also, PPARα expression, on most of the leucocytic populations, was inversely correlated with waist circumferences among the study populations.
Conclusion: Circulated eosinophilic expression of PPARα protein is reduced in MS subjects. This conclusion may explain the endothelial dysfunction and obesity associated with MS, as well as it may help in the management of this worldwide health problem.
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Article Synopsis
- The pparab subtype in zebrafish is strongly expressed in high oxidative tissues and its deficiency reduces fatty acid β-oxidation in both liver and muscle, similar to the role of PPARα in mammals.
- Knockout of pparab leads to increased glucose utilization and inhibited amino acid breakdown, showcasing a metabolic shift in energy sources.
- This research offers new insights into PPARα's regulatory role in nutrient metabolism and establishes zebrafish as a valuable model for studying metabolic processes comparably to mammals.
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