AI Article Synopsis
- Partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA) is aimed at reducing ischemia-reperfusion injury during hemorrhagic shock by allowing partial blood flow past the occlusion.
- In a study involving six sheep, researchers measured changes in arterial pressure as the balloon was gradually inflated, finding a strong correlation between the degree of balloon occlusion and blood pressure readings at different points in the circulatory system.
- Results indicated that significant changes in mean arterial pressure occurred with at least 40-49% balloon occlusion, with complete loss of femoral pulse pressure noted at 80% occlusion or higher, demonstrating the technique's potential effectiveness in managing hemorrhagic shock.
Article Abstract
Introduction: Partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA) is a modified REBOA technique designed to help ameliorate ischemia-reperfusion injury. The balloon is partially deflated, allowing a proportion of aortic flow distal to the balloon. The aim of this study is to use an ovine model of haemorrhagic shock to correlate the degree of occlusion to several hemodynamic indices.
Materials And Methods: Six sheep weighing 35-46 kg underwent a controlled venous haemorrhage inside a CT scanner until the systolic arterial pressure (AP) dropped to <90 mmHg. A balloon positioned in an aortic zone I was incrementally filled with 1 mL of saline, with serial measurement of the proximal (carotid artery) and distal (femoral artery) mean APs (MAP) and intra-balloon pressure (IBP), along with CT imaging, following each inflation, until full occlusion was achieved.
Results: A diameter of the aorta at zone I was 16.0 (15.7-17.2) mm, with a cross-sectional area of 212 (194-233) mm. Median volume of saline injected into the balloon until total occlusion was 7.0 (6.3-8.5) mL. During gradual balloon inflation, proximal MAP increased and distal MAP decreased proportionate to the degree of occlusion, in a linear fashion (proximal: r = 0.85, p < 0.001; distal: r = 0.95, p < 0.001). The femoral/carotid (F/C) pressure gradient also demonstrated a linear trend (r = 0.90, p < 0.001). The relationship between percentage occlusion and IBP was sigmoid. MAP values became significantly different at 40-49% occlusion and more (p < 0.01). Furthermore, a drop in the distal pulse pressure from 7.0 (5.5-16.5) to 2.0 (1.5-5.0) mmHg was observed at 80% occlusion. All animals had femoral pulse pressure <5 mmHg at 80% of occlusion and more, which also coincided with the observed loss of pulsatility of the femoral wave-form.
Conclusion: Serial CT angiography at an ovine model of haemorrhagic shock demonstrates a correlation between the femoral MAP, F/C pressure gradient and degree of zone I P-REBOA during the staged partial aortic occlusion. These parameters should be considered potential parameters to define the degree of P-REBOA during animal research and clinical practice.
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| http://dx.doi.org/10.1016/j.injury.2018.04.021 | DOI Listing |
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