This paper presents a preliminary assessment of the distribution and endemicity of dracunculiasis in Nigeria. The disease is found in all 19 States of the Federation and in the Federal Capital Territory of Abuja. It occurs in areas with a dry season of more than nine months as well as those with a dry season of less than four months; the seasonal distribution of rainfall influences the peak period of disease transmission and patency. Altogether, an estimated 2.5 million cases occur every year, and at least 30% of the entire rural population is at risk from the infection. The widespread distribution of dracunculiasis throughout the country indicates the need for a national control campaign and a sustained programme of international cooperation.
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http://dx.doi.org/10.1093/ije/17.2.428 | DOI Listing |
Am J Trop Med Hyg
September 2024
Guinea Worm Eradication Program, The Carter Center, Atlanta, Georgia.
A comprehensive understanding of the spatial distribution and correlates of infection are key for the planning of disease control programs and assessing the feasibility of elimination and/or eradication. In this work, we used species distribution modeling to predict the environmental suitability of the Guinea worm (Dracunculus medinensis) and identify important climatic and sociodemographic risk factors. Using Guinea worm surveillance data collected by the Chad Guinea Worm Eradication Program (CGWEP) from 2010 to 2022 in combination with remotely sensed climate and sociodemographic correlates of infection within an ensemble machine learning framework, we mapped the environmental suitability of Guinea worm infection in Chad.
View Article and Find Full Text PDFTrop Med Infect Dis
November 2022
Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, 70121 Bari, Italy.
Background: Dracunculiasis, also known as Guinea worm disease (GWD), is a neglected tropical disease (NTD) caused by a parasite (). In the past, dracunculiasis was known as "the disease of the empty granary" because of the difficulties patients had in going to work in fields or to school when affected by this disease. In tropical areas, the condition has been widespread in economically disadvantaged communities, and has been associated with reduced economic status and low levels of education.
View Article and Find Full Text PDFCrit Rev Toxicol
February 2022
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City, Mexico.
Temephos (,,','-tetramethyl ,'-thiodi--phenylene bis(phosphorothioate)) is a larvicide belonging to the family of organophosphate pesticides used for the control of different vectors of diseases, such as dengue, Zika, chikungunya, and dracunculiasis. The aim of this review was to discuss the available published information about temephos toxicokinetics and toxicity in mammals. Temephos is quickly absorbed in the gastrointestinal tract, distributed to all organs, and then it accumulates mainly in adipose tissue.
View Article and Find Full Text PDFPLoS Negl Trop Dis
July 2021
Institute for Disease Modeling, Global Health Division of the Bill and Melinda Gates Foundation, Seattle, Washington, United States of America.
Background: Guinea worm (Dracunculus medinensis) was detected in Chad in 2010 after a supposed ten-year absence, posing a challenge to the global eradication effort. Initiation of a village-based surveillance system in 2012 revealed a substantial number of dogs infected with Guinea worm, raising questions about paratenic hosts and cross-species transmission.
Methodology/principal Findings: We coupled genomic and surveillance case data from 2012-2018 to investigate the modes of transmission between dog and human hosts and the geographic connectivity of worms.
Am J Trop Med Hyg
May 2021
1Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
The total number of Guinea worm cases has been reduced by 99.9% since the mid-1980s when the eradication campaign began. Today, the greatest number of cases is reported from Chad.
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