AI Article Synopsis
- * Research shows that high-fructose diets can raise DNL and liver fat levels, while reducing fructose intake has the opposite effect.
- * The link between high-carbohydrate/sugar diets and NAFLD may be partly due to sugar's ability to boost liver fat production.
Article Abstract
Purpose Of Review: To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD).
Recent Findings: A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat.
Summary: The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL.
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| http://dx.doi.org/10.1097/MCO.0000000000000469 | DOI Listing |
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