AI Article Synopsis
- The orf virus, part of the poxvirus family, is a zoonotic virus primarily affecting sheep, goats, and oxen, and can be transmitted to humans, causing various skin lesions.
- In rare cases, the virus can lead to significant blood vessel growth (vasculoendothelial proliferation) due to a viral gene similar to mammalian vascular endothelial growth factors.
- A case study is reported involving a 6-year-old boy who experienced extensive vascular growth caused by the orf virus, which occurred ten days after he sustained a thermal burn.
Article Abstract
The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. The vascular endothelial growth factor-like viral gene product is expressed early during infection and could be responsible for the induction of endothelial proliferation. Here, a 6-year-old male patient with poxvirus-induced widespread vascular angiogenesis is presented, which developed ten days after a thermal burn.
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| http://dx.doi.org/10.1097/DAD.0000000000001138 | DOI Listing |
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