Black carbon (BC) is a fraction of airborne PM emitted by combustion, causing deleterious effects on human health. Due to its abundance in cities, assessing personal exposure to BC is of utmost importance. Personal exposure and dose of six couples with different working routines were determined for 48 h based on 1-min mobile BC measurements and on ambient concentrations monitored simultaneously at home (outdoor) and at a suburban site. Although couples spent on average ~ 10 h together at home, the routine of each individual in other microenvironments led to 3-55% discrepancies in exposure between partners. The location of the residences and background concentrations accounted for the differences in inter-couple exposure. The overall average exposure and dose by gender were not statistically different. The personal exposure and dose calculated with datasets from fixed sites were lower than the calculations using data from mobile measurements, with the largest divergences (between four and nine times) in the transport category. Even though the individuals spent only 7% of the time commuting, this activity contributed to between 17 and 20% of the integrated exposure and inhaled dose, respectively. On average, exposure was highest on bus trips, while pedestrians and bus passengers had lower doses. Open windows elevated the in-car exposure and dose four times compared to settings with closed windows.
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http://dx.doi.org/10.1007/s11356-018-2045-8 | DOI Listing |
Environ Toxicol Chem
January 2025
Osnabrück University, Osnabrück, Lower Saxony, Germany.
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Nephrology Department, Liangping Hospital, Liangping District People's Hospital of Chongqing, 405299, Chongqing, China.
The current study examined the underlying mechanism and the effect of 1,3-thiazin-6-one on the growth of renal cancer. The findings showed that 1,3-thiazin-6-one treatment inhibited the growth of xenograft tumors in a dose-dependent manner in mice model of renal cancer. Furthermore, when 1,3-thiazin-6-one was administered in a dose-dependent manner to mice with renal cancer, the expression of the proteins p-PI3K and p-Akt significantly decreased.
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State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098, Moscow, Russia.
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January 2025
Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel.
Positron emission tomography (PET) imaging plays a pivotal role in oncology for the early detection of metastatic tumors and response to therapy assessment due to its high sensitivity compared to anatomical imaging modalities. The balance between image quality and radiation exposure is critical, as reducing the administered dose results in a lower signal-to-noise ratio (SNR) and information loss, which may significantly affect clinical diagnosis. Deep learning (DL) algorithms have recently made significant progress in low-dose (LD) PET reconstruction.
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Scientist Emeritus, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Hexabromocyclododecane (HBCD) is a brominated flame retardant, that is added, but not chemically bonded, to consumer products. HBCD is sold as a commercial-grade HBCD mixture containing three major stereoisomers: alpha (α), beta (β), and gamma (γ), with relative amounts of 12% for α-HBCD, 6% for β-HBCD, and 82% for γ-HBCD. HBCDs are widely measured in the environment and in biological matrices.
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