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Cemiplimab in recurrent cervical cancer: Final analysis of overall survival in the phase III EMPOWER-Cervical 1/GOG-3016/ENGOT-cx9 trial.
Eur J Cancer
January 2025
Department of Gynecology and Obstetrics, University of California, Irvine, CA, USA.
Aim: Cemiplimab has demonstrated significantly longer survival than physician's choice of chemotherapy in patients with recurrent cervical cancer after first-line platinum-containing chemotherapy. We report the final survival analysis from the phase III randomized study (EMPOWER-Cervical 1/GOG-3016/ENGOT-cx9).
Methods: Cemiplimab (n = 304) or chemotherapy (n = 304) were administered every 3 weeks.
Long-term effect of non-invasive brain stimulation on hemispatial neglect, functional outcomes, and mortality after stroke: ELETRON trial extend.
Clin Neurol Neurosurg
January 2025
Department of Neurocience and Mental Health, Botucatu Medical School (UNESP), Botucatu, São Paulo, Brazil.
Introduction: Our primary clinical trial indicated that anodal stimulation of the right posterior parietal region associated with specific and perceptual task training was superior to placebo in reducing stroke-induced hemispatial neglect (HN) immediately after the treatment protocol. However, our primary study did not investigate whether this benefit was maintained in the long term after stroke. Therefore, this study aimed to evaluate the long-term effects of the protocol applied in the ELETRON trial on outcomes associated with HN, functionality, and mortality.
View Article and Find Full Text PDFEnvironmental and human health risk assessment of potentially toxic elements in rehabilitating iron mine lands in the Brazilian Amazon.
J Environ Manage
January 2025
Instituto Tecnológico Vale, Rua Boaventura da Silva, 955, Belém, 66055-090, PA, Brazil. Electronic address:
Waste pile substrates from Fe mining may carry potentially toxic elements (PTE). Rehabilitation efforts must maintain soil vegetation cover effectively, avoiding the dispersion of particulate matter and reducing the risk to the environment and human health. Therefore, this study aims to evaluate the pseudo-total and extractable contents, perform chemical fractionation, and assess the bioaccessibility and risk of PTE in waste piles of Fe mining in the Eastern Amazon.
View Article and Find Full Text PDFFrom overgrazed land to forests: assessing soil health in the Caatinga biome.
J Environ Manage
January 2025
Federal Rural University of Pernambuco, Department of Agronomy, Dom Manoel de Medeiros Street, w/n, Recife, PE, 52171-900, Brazil. Electronic address:
Overgrazing is the primary human-induced cause of soil degradation in the Caatinga biome, intensely threatening lands vulnerable to desertification. Grazing exclusion, a simple and cost-effective practice, could restore soils' ecological functions. However, comprehensive insights into the effects of overgrazing and grazing exclusion on Caatinga soils' multifunctionality are lacking.
View Article and Find Full Text PDFFunctional Capacity Among Brazilian Older Adults 12 Months After COVID-19 Infection: A Cross-Sectional Study.
J Clin Med
December 2024
Department of Postgraduate Nursing, State University of Maringá, Avenida Colombo, 5790-Campus Universitário, Maringá 87020-900, Brazil.
Evidence suggests that older adults who survived COVID-19 were exposed to greater functional dependence in their daily living activities. This study aims to examine the prevalence of functional dependence and associated factors among Brazilian older people with functional dependence 12 months after COVID-19 infection. A cross-sectional study was carried out involving people aged 60 years or older in the state of Paraná, Brazil.
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