This paper presents a massively parallel and scalable neuromorphic cortex simulator designed for simulating large and structurally connected spiking neural networks, such as complex models of various areas of the cortex. The main novelty of this work is the abstraction of a neuromorphic architecture into clusters represented by minicolumns and hypercolumns, analogously to the fundamental structural units observed in neurobiology. Without this approach, simulating large-scale fully connected networks needs prohibitively large memory to store look-up tables for point-to-point connections. Instead, we use a novel architecture, based on the structural connectivity in the neocortex, such that all the required parameters and connections can be stored in on-chip memory. The cortex simulator can be easily reconfigured for simulating different neural networks without any change in hardware structure by programming the memory. A hierarchical communication scheme allows one neuron to have a fan-out of up to 200 k neurons. As a proof-of-concept, an implementation on one Altera Stratix V FPGA was able to simulate 20 million to 2.6 billion leaky-integrate-and-fire (LIF) neurons in real time. We verified the system by emulating a simplified auditory cortex (with 100 million neurons). This cortex simulator achieved a low power dissipation of 1.62 μW per neuron. With the advent of commercially available FPGA boards, our system offers an accessible and scalable tool for the design, real-time simulation, and analysis of large-scale spiking neural networks.
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http://dx.doi.org/10.3389/fnins.2018.00213 | DOI Listing |
Biomedicines
December 2024
Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202 Geneva, Switzerland.
The cerebral microvasculature forms a dense network of interconnected blood vessels where flow is modulated partly by astrocytes. Increased neuronal activity stimulates astrocytes to release vasoactive substances at the endfeet, altering the diameters of connected vessels. Our study simulated the coupling between blood flow variations and vessel diameter changes driven by astrocytic activity in the rat somatosensory cortex.
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Institute of AI for Industries, Chinese Academy of Sciences, 168 Tianquan Road, Nanjing 211100, China.
Stereo-orientation selectivity is a fundamental neural mechanism in the brain that plays a crucial role in perception. However, due to the recognition process of high-dimensional spatial information commonly occurring in high-order cortex, we still know little about the mechanisms underlying stereo-orientation selectivity and lack a modeling strategy. A classical explanation for the mechanism of two-dimensional orientation selectivity within the primary visual cortex is based on the Hubel-Wiesel model, a cascading neural connection structure.
View Article and Find Full Text PDFNeuropsychologia
January 2025
Neuroscience Area, SISSA, Trieste, Italy; Dipartimento di Medicina dei Sistemi, Università di Roma-Tor Vergata, Roma, Italy.
Although gesture observation tasks are believed to invariably activate the action-observation network (AON), we investigated whether the activation of different cognitive mechanisms when processing identical stimuli with different explicit instructions modulates AON activations. Accordingly, 24 healthy right-handed individuals observed gestures and they processed both the actor's moved hand (hand laterality judgment task, HT) and the meaning of the actor's gesture (meaning task, MT). The main brain-level result was that the HT (vs MT) differentially activated the left and right precuneus, the left inferior parietal lobe, the left and right superior parietal lobe, the middle frontal gyri bilaterally and the left precentral gyrus.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Ernst Strüngmann Institute, Frankfurt am Main 60528, Germany.
The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings.
View Article and Find Full Text PDFProc IEEE Int Symp Biomed Imaging
May 2024
Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Utilizing a multi-task deep learning framework, this study generated synthetic CT (sCT) images from a limited dataset of Ultrashort echo time (UTE) MRI for transcranial focused ultrasound (tFUS) planning. A 3D Transformer U-Net was employed to produce sCT images that closely replicated actual CT scans, demonstrated by an average Dice coefficient of 0.868 for morphological accuracy.
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