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Cystic fibrosis in Pakistan: population harbouring rare variants non-responsive to CFTR modulators and the dilemma of poor health facilities.
Mol Biol Rep
January 2025
Centre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan.
Background: Pathogenic mutations in the CFTR gene disrupt the normal function of the chloride ion channel CFTR protein, resulting in Cystic Fibrosis (C.F.).
View Article and Find Full Text PDFWhen We Make Errors and Do Harm: A Narrative Review of Second Victim Syndrome and Implications for Neuro-Ophthalmologists.
J Neuroophthalmol
January 2025
Faculty of Medicine (DR), Tel Aviv University, Tel Aviv, Israel; Departments of Ophthalmology and Visual Sciences (LBD), University of Michigan, Ann Arbor, Michigan; and Department of Ophthalmology and Vision Science (EM), University of Toronto, Toronto, Canada.
Background: In the aftermath of an adverse event, the first priority is to provide care for the patient, known as the first victim. However, the experiences of healthcare professionals (HCPs) involved in these events, known as "second victims", have been largely overlooked. This review aims to consolidate existing knowledge on second victim syndrome (SVS), explore its unique implications for neuro-ophthalmologists, and suggest support strategies to increase awareness and meet the needs of affected colleagues.
View Article and Find Full Text PDFDesmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma.
BMC Oral Health
January 2025
Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Key Laboratory of Cancer Prevention and Therapy, West Huan-Hu Rd, Ti Yuan Bei, Hexi District, Tianjin, 300060, P.R. China.
Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with alarmingly high morbidity. The cancer-associated fibroblasts (CAFs) play a pivotal role in tumor development, while their specific mechanisms in OSCC remains largely unclear. Our object is to explore a CAFs-related biomarker in OSCC.
View Article and Find Full Text PDFPrevalence and risk factors of chemotherapy-induced taste alterations among cancer patients: A systematic review and meta-analysis.
Eur J Oncol Nurs
November 2024
School of Nursing, Sun Yat-sen University, Guangzhou, China. Electronic address:
Article Synopsis
- This study investigates the prevalence and risk factors of chemotherapy-induced taste alterations (CiTA) among cancer patients, which can lead to gastrointestinal issues and malnutrition.
- The analysis included 30 studies with over 15,000 participants, finding that 70% of patients experience CiTA, with prevalence varying widely between 21% and 100%.
- Key risk factors identified for developing CiTA include being female, having xerostomia or oral mucositis/ulcers, and undergoing at least two chemotherapy cycles; these findings suggest a need for targeted interventions in healthcare.
"Behavioural and metabolic risk factors of cardiovascular diseases among post-menopausal women: A cross-sectional study in Itahari sub-metropolitan city of Nepal".
PLoS One
November 2024
Faculty of School of Public Health and Community Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Background And Objectives: Cardiovascular diseases (CVDs) are main cause of mortality and morbidity among women globally. Menopause, aging and different factors in collaboration leads to increased risk for CVDs among postmenopausal women but study on risk factors of CVDs among postmenopausal women is limited in Nepal. Therefore, we aimed to assess prevalence of behavioural and metabolic risk factors of cardiovascular disease among post-menopausal women.
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