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Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021.
Biomark Res
January 2025
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background And Objective: Esophageal cancer (EC) is the seventh most prevalent cancer globally and the sixth leading cause of cancer-related mortality. This study aimed to provide an updated stratified assessment of rates in EC incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 by sex, age, and Socio-demographic Index (SDI) at global, regional, and national levels, as well as to project the future trends of EC both globally and regionally.
Methods: Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study.
Vector induced humoral responses after rVSVΔG-ZEBOV-GP immunization identify vaccinated individuals and correlate with Ebola virus glycoprotein antibodies.
J Infect Dis
December 2024
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Background: The robustness and persistence of vaccine antigen-induced antibodies are often used as proxy indicators of vaccine efficacy, but immune responses to vaccine vectors are typically less well-defined. Our study considered the kinetics of immunoglobulin (IgG) responses against the vector (vesicular stomatitis Indiana virus [VSIV]) nucleoprotein (N) and the inserted antigen (Ebola virus [EBOV]) glycoprotein (GP1,2) components of the rVSVΔG-ZEBOV-GP (rVSV-ZEBOV) vaccine and evaluated their use as biomarkers to confirm self-reported vaccination status.
Methods: From the Partnership for Research on Ebola Virus in Liberia (PREVAIL) I clinical trial (NCT02344407), we randomly selected 212 participants who received rVSV-ZEBOV (n=107) or placebo (n=105).
Similar health emergencies, different commitments: Comparative strategies to end Ebola and COVID-19 in "post-conflict" Liberia.
Soc Sci Med
January 2025
The Department of Geography and Environment, Western University, London, Ontario, Canada. Electronic address:
Liberia, in the face of two consecutive health emergencies - the Ebola epidemic in 2014 and COVID in 2019 - offers a unique, comparative perspective on health crisis management within a fractured healthcare system. In dialogue with a feminist-informed political economy of health in the African context, this paper has two central objectives. First, it examines the strategies employed by community-based women's organisations - many of whom remain invested in peacebuilding after a 14-year civil war (1989-2003)) - to contain the Ebola and COVID-19 disease outbreaks.
View Article and Find Full Text PDFSystematic Review and Meta-Analysis of Female Reproductive Health Following Ebola Virus Disease.
Am J Trop Med Hyg
December 2024
Department of Medicine, Section of Infectious Diseases, School of Medicine, Tulane University, New Orleans, Louisiana.
Article Synopsis
- The systematic review focuses on reproductive health issues faced by female survivors of Lassa fever and Ebola virus disease.
- Thirteen studies reviewed predominantly highlight negative outcomes related to reproductive health among EVD survivors, including menstrual irregularities and pregnancy loss, with no research identified on LF survivors.
- The analysis indicates that about 14% of female EVD survivors experience adverse reproductive health outcomes, revealing a significant need for further research in this area.
One term to transform: universal health coverage through professional community health workers.
Lancet
December 2024
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
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