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Identification and characterization of the Cul t 1 as major allergen from biting midge Culicoides tainanus.
Mol Immunol
January 2025
Department of Cell Biology, School of Preclinical Medicine, Zunyi Medical University, Zunyi, Guizhou 563003, China. Electronic address:
Background: Midges are widely distributed globally. They can transmit numerous serious diseases as well as trigger an allergic reaction in the host. Their saliva contains a variety of proteins that act as sensitizers to stimulate the host's immune response, leading to IgE-mediated allergic symptoms.
View Article and Find Full Text PDFIdentification of Rickettsia species in cattle ticks in selected regions of urban Ghana.
Med Vet Entomol
January 2025
Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Ticks continue to invade new regions spreading pathogens of zoonotic and veterinary importance. Diverse tick species have been reported in Ghana due to the continuous trade of livestock. In this study, ticks were collected from cattle in three sites within Southern Ghana.
View Article and Find Full Text PDFTarget-agnostic identification of human antibodies to sexual forms reveals cross-stage recognition of glutamate-rich repeats.
Elife
January 2025
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
Circulating sexual stages of ) can be transmitted from humans to mosquitoes, thereby furthering the spread of malaria in the population. It is well established that antibodies can efficiently block parasite transmission. In search for naturally acquired antibodies targets on sexual stages, we established an efficient method for target-agnostic single B cell activation followed by high-throughput selection of human monoclonal antibodies (mAbs) reactive to sexual stages of in the form of gametes and gametocyte extracts.
View Article and Find Full Text PDFPurification and transcriptomic characterization of proliferative cells of selectively affected by irradiation.
Front Parasitol
March 2024
Departamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Flatworms depend on stem cells for continued tissue growth and renewal during their life cycles, making these cells valuable drug targets. While neoblasts are extensively characterized in the free-living planarian , and similar stem cells have been characterized in the trematode , their identification and characterization in cestodes is just emerging. Since stem cells are generally affected by irradiation, in this work we used this experimental approach to study the stem cells of the model cestode .
View Article and Find Full Text PDFIdentification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against c-Jun N-terminal kinase SMJNK.
Front Parasitol
April 2024
Institut für Parasitologie, Biomedizinisches Forschungszentrum Seltersberg (BFS), Justus Liebig Universitaet Giessen, Giessen, Germany.
Introduction: Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful level of selectivity, there is a compelling need to expand the chemical space available for synthesizing new, potent, and selective PK inhibitors. Small-molecule inhibitors targeting the ATP pocket of the catalytic domain of PKs have the potential to become drugs devoid of (major) side effects, particularly if they bind selectively.
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