AI Article Synopsis
- A new research study on Carpesium humile Winkl, a plant species native to China, identified two new compounds (germacranolides) and one new phytane diterpene, along with five previously known compounds.
- The structures of the new compounds were determined using advanced techniques like NMR, CD exciton chirality, and X-ray crystallography.
- Additionally, several of the isolated compounds exhibited significant cytotoxic effects against various human cancer cell lines, indicating their potential as anti-cancer agents.
Article Abstract
Carpesium humile Winkl is an endemic Chinese species and no previous phytochemical studies have been reported for this species. Two new germacranolides (1 and 2) and a new phytane diterpene (5), together with five known compounds (two sesquiterpenoids and three diterpenoids), were isolated from the aerial parts of C. humile. Their structures were elucidated on the basis of extensive spectroscopic analysis. The conformations and absolute configurations of 1 and 2 were established by combinative analysis of NMR, CD exciton chirality, and X-ray crystallography data. Four germacranolides (1-4) showed strong cytotoxic activities, with broad spectrum activities against six human cancer (HepG2, HeLa, HL60, SGC7901, Lewis, and MDA231) cell lines in vitro using MTT assay, with IC values from 3.09 to 7.71 μg/mL. Diterpenes (5, 6, and 8) also displayed good cytotoxic activities for selected cancer cell lines, with IC values in the range 5.46-8.08 μg/mL.
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| http://dx.doi.org/10.1016/j.fitote.2018.04.015 | DOI Listing |
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