Moseley discusses the molecular and mechanical functions of eisosomes - invaginations from the yeast plasma membrane.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214159 | PMC |
| http://dx.doi.org/10.1016/j.cub.2017.11.073 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eisosomes.
Curr Biol
April 2018
Department of Biochemistry and Cell Biology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address:
Moseley discusses the molecular and mechanical functions of eisosomes - invaginations from the yeast plasma membrane.
View Article and Find Full Text PDFCytoskeletal polymers are organized into a wide variety of higher-order structures in cells. The yeast BAR domain protein Pil1 self-assembles into tubules in vitro, and forms linear polymers at cortical eisosomes in cells. In the fission yeast S.
View Article and Find Full Text PDFEisosomes provide membrane reservoirs for rapid expansion of the yeast plasma membrane.
J Cell Sci
November 2015
Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
Cell surface area rapidly increases during mechanical and hypoosmotic stresses. Such expansion of the plasma membrane requires 'membrane reservoirs' that provide surface area and buffer membrane tension, but the sources of this membrane remain poorly understood. In principle, the flattening of invaginations and buds within the plasma membrane could provide this additional surface area, as recently shown for caveolae in animal cells.
View Article and Find Full Text PDFEisosomes Regulate Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Cortical Clusters and Mitogen-activated Protein (MAP) Kinase Signaling upon Osmotic Stress.
J Biol Chem
October 2015
From the Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755 and
Eisosomes are multiprotein structures that generate linear invaginations at the plasma membrane of yeast cells. The core component of eisosomes, the BAR domain protein Pil1, generates these invaginations through direct binding to lipids including phosphoinositides. Eisosomes promote hydrolysis of phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) by functioning with synaptojanin, but the cellular processes regulated by this pathway have been unknown.
View Article and Find Full Text PDFA Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation.
J Cell Sci
March 2014
Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Stable compartments of the plasma membrane promote a wide range of cellular functions. In yeast cells, cytosolic structures called eisosomes generate prominent cortical invaginations of unknown function. Through a series of genetic screens in fission yeast, we found that the eisosome proteins Pil1 and Sle1 function with the synaptojanin-like lipid phosphatase Syj1 and its ligand Tax4.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!