The physician as well as the health care system, are both facing the challenge of chronic conditions. Multi-morbidity is very common in many of the patients with chronic conditions (defined by the WHO as a disease with the duration of more than twelve months). Most of these patients are elderly with deterioration in their physiological systems' reserves. The clinical research in chronic diseases is trying to separate the disease from other conditions in order to achieve specific therapeutic conclusions for the disease. According to research results, guidelines are established for the treatment of the diseases. In recent years, new approaches to patients with chronic multi-morbidity have been developed. These approaches use individual approaches to the patient, establishing the goals of care according to the patient's view concerning his/her capacities to carry the workload that is associated with the treatment regime. Minimal Disruptive Medicine-MDM is an approach which originated in American Medicine. The aim of this paper is to introduce the different aspects of this approach, their origin and basis and its benefit to the chronic patient today. This approach encourages the patient and his physician to optimize the quality of care.
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