AI Article Synopsis
- GALT carcinoma is a rare type of colorectal cancer found in gut-associated lymphoid tissue, with only 26 cases reported and typically low progression rates.
- Most cases are diagnosed early and show no signs of metastasis, indicating a generally favorable prognosis.
- Research using immunohistochemistry and electron microscopy revealed that GALT carcinoma cells do not originate from M cells, suggesting it may arise independently within GALT tissue.
Article Abstract
Aims: Gut-associated lymphoid tissue (GALT) carcinoma is a rare colorectal tumour that arises in the epithelium covering GALT. GALT carcinoma is a differentiated tubular adenocarcinoma with dense lymphoid tissue with a characteristically well-demarcated margin. To date, 26 cases of GALT carcinoma, including the three cases discussed here, have been reported. Most (24 of 26) were discovered at early stages and none of the cases have documented any metastases. This suggests that GALT carcinoma may have a favourable prognosis. It is hypothesised that GALT carcinoma originates from M cells in specialised epithelia covering GALT. However, this hypothesis has yet to be confirmed.
Methods And Results: In this study, we examined three cases of GALT carcinoma by immunohistochemistry detection of glycoprotein 2, a specific marker for M cells, and electron microscopy. Our findings showed that the tumour cells of GALT carcinoma in all three cases were negative for M cells. We thus concluded that GALT carcinoma may be a tubular adenocarcinoma arising by chance in the GALT. This unique carcinoma is a diferentiated adenocarcinoma that grows slowly with the development of GALT.
Conclusions: We propose that GALT carcinoma should be classified separately because of its histological setting and good prognosis.
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| http://dx.doi.org/10.1111/his.13639 | DOI Listing |
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