AI Article Synopsis
- Gonadotropins, especially LH-RH, are linked to ovarian cancer development, and blocking certain hormones may have therapeutic potential.
- Researchers tested D-Trp-6-LH-RH, a synthetic version of LH-RH, in a rat model of ovarian cancer that mimics human tumors.
- Monthly treatments with D-Trp-6-LH-RH showed promising results, extending survival and reducing tumor growth and spread, but further studies are necessary to confirm these findings.
Article Abstract
Hormones, particularly gonadotropins, have been implicated in the development of ovarian cancer. Chronic administration of agonistic analogs of luteinizing-hormone releasing-hormone (LH-RH) induces an inhibition of the pituitary-gonadal axis. The blockade of the release of luteinizing-hormone and follicle-stimulating hormone (FSH) may exert a possible therapeutic effect on ovarian cancer. We examined the results of prolonged administration of D-Trp-6-LH-RH, an agonistic analog of LH-RH in experimental ovarian cancer. We used the recently developed ovarian cancer model in rats, which is produced by treatment of pregnant rats with N-nitrosobis(2-oxopropyl)amine (BOP), following which a high incidence of ovarian tumors are induced in the offspring. In morphologic aspects the induced tumor resembles human ovarian neoplasms. Once a month administration of a delayed release preparation of microcapsules of D-Trp-6-LH-RH prolonged the survival and decreased tumor growth and the incidence of metastases. Additional experimental and clinical studies are needed to determine the efficacy of the treatment with LH-RH analogs in ovarian cancer.
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| http://dx.doi.org/10.1016/0304-3835(88)90061-4 | DOI Listing |
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