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Fusion of FDG and FMZ PET Reduces False Positive in Predicting Epileptogenic Zone.
AJNR Am J Neuroradiol
January 2025
From the School of Biomedical Engineering (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China; Department of Neurosurgery (S.J., J.H., L.C.), and PET Center (W.B.), Huashan Hospital, Fudan University, Shanghai, China.
Background And Purpose: Epilepsy, a globally prevalent neurological disorder, necessitates precise identification of the epileptogenic zone (EZ) for effective surgical management. While the individual utilities of FDG PET and FMZ PET have been demonstrated, their combined efficacy in localizing the epileptogenic zone remains underexplored. We aim to improve the non-invasive prediction of epileptogenic zone (EZ) in temporal lobe epilepsy (TLE) by combining FDG PET and FMZ PET with statistical feature extraction and machine learning.
View Article and Find Full Text PDFData-driven prediction of regional brain metabolism using neuropsychological assessment in Alzheimer's disease and behavioral variant Frontotemporal dementia.
Cortex
December 2024
Departments of Neurology and Nuclear Medicine, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Spain. Electronic address:
Background: This study aimed to evaluate the capacity of neuropsychological assessment to predict the regional brain metabolism in a cohort of patients with amnestic Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using Machine Learning algorithms.
Methods: We included 360 subjects, consisting of 186 patients with AD, 87 with bvFTD, and 87 cognitively healthy controls. All participants underwent a neuropsychological assessment using the Addenbrooke's Cognitive Examination and the Neuronorma battery, in addition to [F]-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging.
Urinary formic acid is associated with cerebral amyloid deposition and glucose metabolism in memory clinic patients.
J Alzheimers Dis
January 2025
Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Urinary formic acid (FA) has been reported to be a biomarker for Alzheimer's disease (AD). However, the association between FA and pathological changes in memory clinic patients is currently unclear.
Objective: This study aims to investigate associations between FA and pathological changes across different cognitive statuses in memory clinic patients.
Neuroprotective potential of isofraxidin: Alleviating parkinsonian symptoms, inflammation and microglial activation.
J Cent Nerv Syst Dis
January 2025
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Background: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Previous research has confirmed that isofraxidin can reduce macrophage expression and inhibit peripheral inflammation. However, its effects on the central nervous system remain underexplored.
View Article and Find Full Text PDFThe role and mechanism of HMGB1-mediated Notch1/Hes-1 pathway in anxiety and depression-like behaviors in mice with chronic rhinosinusitis.
Mol Med
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Background: Chronic rhinosinusitis (CRS) is a global health issue, with some patients experiencing anxiety and depression-like symptoms. This study investigates the role of HMGB1 in anxiety and depression-like behaviors associated with the microglial Notch1/Hes-1 pathway in CRS mice.
Methods: A CRS mouse model was developed, and behavioral assessments were conducted to evaluate anxiety and depression-like behaviors.
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