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Primary malignant melanoma of the lung: a case report of a rare tumor and review of the literature. | LitMetric

AI Article Synopsis

  • Primary malignant melanoma of the lung (PMML) is a rare and aggressive cancer with a poor prognosis, as illustrated by a case of a 22-year-old male who experienced coughing and significant weight loss.
  • The patient's lung scans revealed a large tumor in the right lower lobe, leading to a diagnosis of poorly differentiated carcinoma following biopsies, with no signs of lymphatic spread.
  • After undergoing surgery to remove the tumor, the patient has been successfully tumor-free for three years with no additional treatments needed.

Article Abstract

Primary malignant melanoma of the lung (PMML) is a rare malignancy that exhibits aggressive behavior and has a very poor prognosis. We are reporting on a case of PMML in an otherwise healthy 22-year-old Caucasian male with no significant past medical history and an unremarkable family history. The patient initially presented with a 2-month history of a cough and an unexplained 22-lb weight loss. His initial chest X-ray demonstrated opacification of the right lower lobe (RLL) of his lung and a subsequent computerized tomography scan (CT scan) of his lung revealed a large mass occupying most of his RLL (Figure 1). The patient subsequently underwent a bronchoscopy with endobronchial ultrasound. Biopsies revealed a poorly differentiated carcinoma. A positron emission tomography with low dose CT scan was performed per protocol and revealed an intensely hypermetabolic tumor with no evidence for lymphatic disease or extra-thoracic spread. The patient underwent a surgical exploration and a right lower lobectomy with a thoracic lymphadenectomy. The pathology including immunohistochemical stains demonstrated a malignant melanoma with no lymph node involvement. A physical examination including ophthalmic, mucosal, and skin examinations revealed no evidence for an extra-thoracic site of the disease. The patient had negative margins for resection and did not receive any adjuvant therapy and is alive and well with no evidence for recurrence 3 years after the resection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901268PMC
http://dx.doi.org/10.1080/20009666.2018.1424485DOI Listing

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