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Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option. | LitMetric
Background And Aims : Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. We aimed to assess clinical advantages of MSCT in patients with LF.Methods : Clinical researches reporting MSCT in LF patients were searched and included.Results : Nine articles ( = 476) related with LF patients were enrolled. After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month ( < 0.05); total bilirubin (TBIL) baseline declined to a certain stable level of 78.57 mol/L at 2 and 3 months ( < 0.05). Notably, the decreased value ( value) of Model for End-Stage Liver Disease score (MELD) of acute-on-chronic liver failure (ACLF) group was higher than that of chronic liver failure (CLF) group (14.93 ± 1.24 versus 4.6 ± 5.66, < 0.05). Moreover, MELD baseline of ≥20 group was a higher D value of MELD than MELD baseline of <20 group with a significant statistical difference after MSCT ( = 0.003).Conclusion : The early assessment of the efficacy of MSCT could be based on variations of ALT at half a month and TBIL at 2 and 3 months. And it had beneficial effects for patients with LF, especially in ACLF based on the value of MELD.
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