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http://dx.doi.org/10.1038/s41434-018-0013-z | DOI Listing |
Immunotherapy
March 2024
Liver Transplant Center, Department of General Surgery, Huashan Hospital, Fudan University, 12 Urumqi Road (M), Shanghai, 200040, China.
Chimeric antigen receptor (CAR) T-cell therapy for malignant tumors has reached a crucial stage, with recent studies underscoring the role of T-cell exhaustion in determining the efficacy of CAR-T therapy. This trailblazing discovery has opened new avenues to augment the potency of CAR-T therapy. Basic leucine zipper ATF-like transcription factor () is indispensable in alleviating T-cell exhaustion and is pivotal in the early stages of CD8 T-cell differentiation.
View Article and Find Full Text PDFGene Ther
June 2018
Novartis Oncology, One Health Plaza, East Hanover, NJ, 07936-1080, USA.
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