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Gingival keratinocyte adhesion on atomic layer-deposited hydroxyapatite coated titanium.
J Biomater Appl
January 2025
Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Turku, Turku, Finland.
his study aimed to evaluate the effects of the atomic layer deposited hydroxyapatite (ALD-HA) coating of the titanium (Ti) surface on human gingival keratinocyte (HGK) cell adhesion, spreading, viability, and hemidesmosome (HD) formation. Grade 2 square-shaped Ti substrates were used ( = 62). Half of the substrates were ALD-HA coated, while the other half were used as non-coated controls (NC).
View Article and Find Full Text PDFEffect of lubricants type and particle size on the rheological properties and aerosolization behavior of dry powder inhalers.
Int J Pharm
December 2024
School of Pharmacy, Shenyang Key Laboratory of Intelligent Mucosal Drug Delivery Systems, Shenyang Pharmaceutical University, Shenyang 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, China. Electronic address:
A commonly used strategy to improve aerosolization behavior of carrier-based dry powder inhalers (DPIs) is the addition of magnesium stearate as a lubricant, yet it may also negatively affect properties of DPIs. Thus, the aim of this study was to find lubricants that could be used as alternatives of magnesium stearate and meanwhile verify the applicability of using powder rheological properties to predict the performance of different lubricants in DPIs. Here, using fluticasone propionate as a model drug, LH200 as the carrier, influence of lubricants type and particle size, including magnesium stearate, sodium stearate, Leucine, sodium stearate fumarate, Compritol® 888 ATO, and Compritol® HD5 ATO, on the physicochemical properties, powder rheology and aerosolization behavior of the DPI formulations was characterized.
View Article and Find Full Text PDFNebulization of Hypoxic hUCMSC-EVs Attenuates Airway Epithelial Barrier Defects in Chronic Asthma Mice by Transferring CAV-1.
Int J Nanomedicine
November 2024
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
Background: Nebulization of hypoxic human umbilical cord mesenchymal stem cell-derived extracellular vesicles (Hypo-EVs) can suppress airway inflammation and remodeling in a chronic asthmatic mouse; however, the exact mechanism remains unclear. Recently, airway epithelial barrier defects have been regarded as crucial therapeutic targets in asthma. The aim of this study was to investigate whether and how Hypo-EVs protect against the disruption of the airway epithelial barrier under asthmatic conditions.
View Article and Find Full Text PDFMultiplex antimicrobial activities of the self-assembled amphiphilic polypeptide β nanofiber KF-5 against vaginal pathogens.
Biol Direct
October 2024
Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Background: Vaginal infections caused by multidrug-resistant pathogens such as Candida albicans and Gardnerella spp. represent a significant health challenge. Current treatments often fail because of resistance and toxicity.
View Article and Find Full Text PDFEfficacy of nebulized GM-CSF inhalation in preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation: A retrospective study.
Heliyon
October 2024
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No.288, Tian-Wen Road, Chongqing, 40000, China.
Article Synopsis
- The study aimed to evaluate the effectiveness of inhaling oxygen atomized granulocyte-macrophage colony-stimulating factor (GM-CSF) in preventing oral mucositis in patients after hematopoietic stem cell transplantation.
- Data was collected from 143 patients treated at the hospital over two years, dividing them into an observation group (who received GM-CSF) and a control group (who did not) while assessing various factors like pain and infection status.
- The patient demographics included a diverse range of ages and conditions, revealing a mix of autologous and allogeneic transplantations, and highlighting the complexities of treating oral mucositis in this population.
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