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Effects of smoking cessation on individuals with COPD: a systematic review and meta-analysis.
Front Public Health
December 2024
Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Objective: Despite smoking being a significant risk factor in the occurrence and progression of chronic obstructive pulmonary disease (COPD), no comprehensive analysis has been conducted to determine the potential benefits of smoking cessation for patients with established COPD or identify specific indicators that may be improved. The aim of our meta-analysis was to elucidate the positive impact of smoking cessation on COPD.
Methods: We conducted a comprehensive search of PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Wan Fang and VIP databases to identify studies that met our eligibility criteria from inception up to 1, May 2024.
A cross-sectional and longitudinal evaluation of serum creatinine as a biomarker in spinal muscular atrophy.
Orphanet J Rare Dis
December 2024
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei province, China.
Objective: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by proximal muscle weakness and atrophy. The increasing availability of disease-modifying therapies has prompted the development of biomarkers to facilitate clinical assessments. We explored the association between disease severity and serum creatinine (Crn) levels in SMA patients undergoing up to two years of treatment with nusinersen.
View Article and Find Full Text PDF[Management before anatomical lung resections: prehabilitation and functional testing].
Khirurgiia (Mosk)
December 2024
Moscow City Clinical Oncology Hospital No. 1, Moscow, Russia.
Objective assessment of respiratory and cardiovascular reserves is important for planning of total resections in patients with non-small cell lung cancer (NSCLC). Chronic obstructive pulmonary disease is one of the leading comorbidities in patients with newly diagnosed NSCLC. Noninvasive assessment of exercise tolerance (6-minute step test, stair test) combined with analysis of external respiratory function and diffusing capacity of lungs underlie basic testing before lung resections.
View Article and Find Full Text PDFLongitudinal anemia status and risk for adverse outcomes in former smokers with COPD.
Respir Res
December 2024
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA.
Background: Anemia is a prevalent comorbidity in COPD associated with increased morbidity. However, the significance of longitudinal anemia status and variation in anemia status trends over time in COPD are not known. Furthermore, individuals with COPD and smoking history often have multiple comorbidities, in particular cardiovascular disease.
View Article and Find Full Text PDFPopulation Pharmacokinetic/Pharmacodynamic and Exposure-Response Modeling Analyses of Sotatercept in Healthy Participants and Patients with Pulmonary Arterial Hypertension.
Clin Pharmacol Ther
December 2024
Merck & Co., Inc., Rahway, New Jersey, USA.
Article Synopsis
- * Enhanced exposure-response and pharmacokinetic/pharmacodynamic modeling revealed that higher concentrations of sotatercept improve key clinical outcomes including 6MWD and the likelihood of achieving lower NT-proBNP levels, while maintaining safety measures like hemoglobin levels.
- * Key factors influencing the treatment's response include patient age and iron supplementation, but their overall impact on outcomes was minimal, supporting the selected dosing strategy of 0.7 mg/kg administered subcutaneously every three weeks as effective and safe.
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