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CRISPR genetic screens to discover host-virus interactions. | LitMetric

CRISPR genetic screens to discover host-virus interactions.

Curr Opin Virol

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA; Gastroenterology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

Published: April 2018

AI Article Synopsis

Article Abstract

Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host-virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host-virus interactions.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2018.03.007DOI Listing

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