We study the motion of a spherical active Brownian particle (ABP) of size a, moving with a fixed speed U0, and reorienting on a time scale τR in the presence of a confining boundary. Because momentum is conserved in the embedding fluid, we show that the average force per unit area on the boundary equals the bulk mechanical pressure P∞ = p∞f + Π∞, where p∞f is the fluid pressure and Π∞ is the particle pressure; this is true for active and passive particles alike regardless of how the particles interact with the boundary. As an example, we investigate how hydrodynamic interactions (HI) change the particle-phase pressure at the wall, and find that Πwall = n∞(kBT + ζ(Δ)U0l(Δ)/6), where ζ is the (Stokes) drag on the swimmer, l = U0τR is the run length, and Δ is the minimum gap size between the particle and the wall; as Δ → ∞ this is the familiar swim pressure [Takatori et al., Phys. Rev. Lett., 2014, 113, 1-5].
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Clin Mol Hepatol
December 2024
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Backgrounds/aims: Transmembrane 4 L six family member 1 (TM4SF1) is highly expressed in and contributes to the progression of various malignancies. However, how it modulates hepatocellular carcinoma (HCC) progression and senescence remains to be elucidated.
Methods: TM4SF1 expression in HCC samples was evaluated using immunohistochemistry and flow cytometry.
PNAS Nexus
January 2025
Université Paris Cité, CNRS, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, Paris 75005, France.
The driving mechanisms at the base of the clearance of biological wastes in the brain interstitial space (ISS) are still poorly understood and an actively debated subject. A complete comprehension of the processes that lead to the aggregation of amyloid proteins in such environment, hallmark of the onset and progression of Alzheimer's disease, is of crucial relevance. Here we employ combined computational fluid dynamics and molecular dynamics techniques to uncover the role of fluid flow and proteins transport in the brain ISS.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, PR China. Electronic address:
The ecological risk of microplastics (MPs) is raising concern about their transport and fate in aquatic ecosystems. The capture of MPs by bubbles is a ubiquitous natural phenomenon in water-based environment, which plays a critical role in the global cycling of MPs, thereby increasing their environmental threats. However, the nanoscale interaction mechanisms between bubbles and MPs underlying MPs transport by bubbles in complex environmental systems remain elusive.
View Article and Find Full Text PDFEur J Pharm Sci
December 2024
Institute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg im Breisgau, Germany; Andreas Hettich GmbH & Co. KG, 78532 Tuttlingen, Germany.
Thermosensitive liposomes (TSLs) have great potential for the selective delivery of cytostatic drugs to the tumor site with greatly reduced side effects. Here we report the discovery and characterization of new thermosensitive small multilamellar lipid nanoparticles (tSMLPs) with unusually high temperature selectivity. Furthermore, the temperature-dependent release of the fluorescent marker calcein from tSMLPs is enhanced by human serum albumin.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
College of Oceanography, Hohai University, Nanjing 210024, China.
In order to figure out the wall effect on the propulsive property of an auto-propelled foil, the commercial open-source code ANSYS Fluent was employed to numerically evaluate the fluid dynamics of flexible foil under various wall distances. A virtual model of NACA0015 foil undergoing travelling wavy motion was adopted, and the research object included 2D and 3D models. To capture the foil's moving boundary, the dynamic grid technique coupled with the overlapping grid was utilized to realize the foil's positive deformation and passive forward motion.
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