O-Heterocycles from Unsaturated Carbonyls and Dimethoxycarbene.

J Org Chem

Département de Chimie , Université de Sherbrooke , 2500 Boulevard Université, Sherbrooke , Quebec J1K 2R1 , Canada.

Published: May 2018

The (4+1)-annulation of dimethoxycarbene with readily accessible α,β-unsaturated carbonyls gives cyclic orthoesters, which can then be converted in just a few steps to other O-heterocycles, including methoxyfurans, furanones, and furans.

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http://dx.doi.org/10.1021/acs.joc.8b00613DOI Listing

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