AI Article Synopsis
- The study investigates the presence and distribution of two calcium-binding proteins (CBPs), calretinin and calbindin, in the retina of the octopus, highlighting its unique evolutionary significance.
- Calretinin was found in both photoreceptor and supporting cells of the octopus retina, while calbindin showed no detectable presence.
- Additionally, the research identified the localization of neuropeptides Substance P and CGRP, suggesting that calretinin may play an important role in visual signal processing in cephalopods.
Article Abstract
The existence of both calcium-binding proteins (CBPs) and neuropeptides in the retina and brain of various species of vertebrates and invertebrates is well documented. Octopus retina is particularly interesting because it represents a case of convergent evolution. The aim of this study was to characterize the distribution of two CBPs, calretinin and calbindin, in Octopus retina using morphology, in situ hybridization, immunocytochemistry and Western blot. Calretinin-like immunoreactivity was found in the photoreceptor cells, but unexpectedly also in the supporting cells. In situ hybridization and Western blot analysis confirmed these results. No immunoreactivity was found for calbindin. Two neuropeptides, Substance P and calcitonin gene-related peptide (CGRP), as well as neurofilament protein and glial fibrillary acidic protein were also localized in the Octopus retina by immunocytochemistry. Our work provides new insights about calcium-binding proteins and neuropeptide distribution in Octopus retina and suggests a functional role for calretinin, a highly conserved protein, in visual signal transduction of cephalopods.
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| http://dx.doi.org/10.1002/jcp.26570 | DOI Listing |
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