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Novel Presentation of Lichenoid Dermatoses Preceding Bullous Pemphigoid Secondary to Immune Checkpoint Inhibitor Therapy.
Skinmed
January 2025
Department of Dermatology, Medical Center, Bronx, NY;
The 73-year-old non-Hispanic, African-American man with a history of renal cell carcinoma (RCC), status post-nephrectomy receiving Lenvatinib, and metastatic disease, for which he also had received nivolumab for 13½ months. An itchy eruption appeared one month after the discontinuation of nivolumab and after the beginning of axitinib therapy. Physical examination revealed pink-violaceous scaly plaques, some with trailing scales on the anterior aspect of the trunk (Figure 1), a slight erosion on the hard palate, and hypopigmentation on the hands and legs.
View Article and Find Full Text PDFAI-Driven Microscopy: Cutting-Edge Approach for Breast Tissue Prognosis Using Microscopic Images.
Microsc Res Tech
January 2025
Artificial Intelligence and Data Analytics (AIDA) lab, CCIS Prince Sultan University, Riyadh, Saudi Arabia.
Microscopic imaging aids disease diagnosis by describing quantitative cell morphology and tissue size. However, the high spatial resolution of these images poses significant challenges for manual quantitative evaluation. This project proposes using computer-aided analysis methods to address these challenges, enabling rapid and precise clinical diagnosis, course analysis, and prognostic prediction.
View Article and Find Full Text PDFPhytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature's secrets in forensic science.
Nat Prod Bioprospect
January 2025
Botany and Microbiology Department, Faculty of Science, Benha University, Benha, 13518, Egypt.
The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented insights into nature's secrets through the precise application of phytochemical fingerprinting of phytotoxins as a cutting-edge approach. This study explores the dynamic intersection of phytochemistry and forensic science, highlighting how the unique phytochemical profiles of toxic plants and their secondary metabolites, serve as distinctive markers for forensic investigations. By utilizing advanced techniques such as Ultra-High-Performance Liquid Chromatography (UHPLC) and High-Resolution Mass Spectrometry (HRMS), the detection and quantification of plant-derived are made more accurate in forensic contexts.
View Article and Find Full Text PDFOcular neuromyotonia after peribulbar block.
J AAPOS
December 2024
Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address:
A man in his 60s developed an intermittent, variable left hypotropia with symptomatic diplopia following nasal pterygium surgery in the left eye. No tropia was present for most of the day, but a variable left hypotropia of 25 could be provoked with downgaze. There was no history of radiation or other trauma.
View Article and Find Full Text PDFIschemic stroke is a significant global health problem associated with mortality and disability. Intracranial atherosclerotic stenosis (ICAS) is a leading cause of stroke and contributes to recurrent stroke, especially in Asian population. Because of the different pathophysiology and mechanisms of ICAS resulting in ischemic stroke compared to extracranial atherosclerotic stenosis (ECAS), treatment strategies for secondary prevention would be different.
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