The 3D structural analysis of 62 peptides derived from highly pathogenic malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ allele family) and modified mmune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.
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| http://dx.doi.org/10.3389/fchem.2018.00106 | DOI Listing |
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