Aim: Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses.
Methodology: Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10. Activity was assessed by measuring cytokine expression upon lipopolysaccharide stimulation, IL-10-induced signaling and down-stream gene expression.
Conclusion: This study describes that GM-CSF negatively regulates IL-10-mediated responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905582 | PMC |
| http://dx.doi.org/10.4155/fsoa-2017-0133 | DOI Listing |
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