AI Article Synopsis
- The study examined how pazufloxacin (PZFX) is absorbed and distributed in the body after a 200mg oral dose given to 6 healthy males.
- In plasma, PZFX reached its peak concentration at 0.7 hours with a maximum level of 2.95μg/mL, and it took 1.75 hours to eliminate half of the drug.
- The drug demonstrated strong penetration into suction blister fluid, achieving similar levels in both blister fluid and plasma, indicating effective distribution in the body.
Article Abstract
We investigated the pharmacokinetics of pazufloxacin (PZFX) in the fluid of suction blisters induced in the skin of 6 healthy male volunteers after a 200mg oral dose of PZFX. The time to reach the maximum concentration (t) of PZFX in plasma was 0.7 hours, and the maximum concentration (C) was 2.95μg/mL. The half-life of the elimination phase (t) in plasma was 1.75 hours, and the area under the concentration-time curve (AUC) was 6.70μg·h/mL. The t, C, t and AUC values in the suction blister fluid were 2.0 hours, 1.52μg/mL, 1.95 hours and 6.28μg·h/mL, respectively. The ratio of the AUC of PZFX in blister fluid to the AUC in plasma was almost 1.0. Thus, excellent penetration of PZFX into suction blister fluid was observed.
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| http://dx.doi.org/10.1007/BF02355129 | DOI Listing |
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