AI Article Synopsis
- - The review explores the presence and functions of natural mono-, di-, and triaromatic steroids, which are produced by various organisms including microorganisms, fungi, and marine invertebrates, and can also be found in plants and animals.
- - Research indicates that about eighty of these aromatic steroids exhibit significant biological activities, particularly in anti-tumor, anti-inflammatory, and neuroprotection, demonstrating a confidence level of 78 to 92%.
- - The findings suggest that aromatic steroids could be vital for drug discovery, making them particularly interesting for professionals in chemistry, medicine, biology, pharmacology, and the pharmaceutical industry.
Article Abstract
The present review describes the distribution and biological activities of natural mono-, di-, and triaromatic steroids. It is shown that the producers of aromatic steroids are microorganisms, fungi, and marine invertebrates, and also they were found in plants, animals, marine sediments, and karst deposits. Eighty biologically active aromatic steroids likely have an anti-tumor, anti-inflammatory, and neuroprotection activity with a confidence of 78 to 92%. The structures and predicted biological activities of aromatic steroids are available. This review emphasizes the role of aromatic steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists, and the pharmaceutical industry.
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| http://dx.doi.org/10.1007/s00253-018-8968-7 | DOI Listing |
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