AI Article Synopsis
- A study evaluated a range of lipo-benzamide compounds with hydrocarbon chains from C2M to C18M for their ability to inhibit Candida fungal growth, identifying four compounds (with 8-11 carbons) that showed effective concentration-dependent inhibition, especially compound C9M with an MIC of ≤6.2 µg/ml.
- Compound C9M was effective against both Candida albicans and non-albicans strains, including those that are sensitive and resistant to azoles, and also inhibited various stages of Candida biofilm development.
- Scanning Electron Microscopy revealed that C9M treatment did not cause significant cell lysis in Candida cells, and a hemolysis assay indicated only 2.5%
Article Abstract
A series of cationic lipo-benzamide compounds with varying lengths of hydrocarbon chains (C2M-C18M) were evaluated for anti-Candida activity. Four compounds harbouring 8-11 hydrocarbon chains demonstrated concentration-dependent inhibition of fungal cell growth with Minimum Inhibitory Concentration (MIC) of ≤6.2 µg ml. The most active compound (C9M) inhibited growth of both Candida albicans and non-albicans strains and is equally active against pairs of azole sensitive and resistant clinical isolates of C. albicans. Compound C9M also inhibited different stages of Candida biofilms. Scanning Electron Microscopy (SEM) of Candida cells after C9M treatment was also done and no significant cell lysis was observed. Hemolysis assay was performed and only 2.5% haemolysis was observed at MIC concentration.
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| http://dx.doi.org/10.1016/j.bmcl.2018.04.024 | DOI Listing |
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