Identifying incident (first or new) episodes of illness is critical in sentinel networks to inform about the seasonal onset of diseases and to give early warning of epidemics, as well as differentiating change in health service utilization from change in pattern of disease. The most reliable way of differentiating incident from prevalent cases is through the clinician assigning episode type to the patient's computerized medical record (CMR). However, episode type assignment is often made inconsistently. The objective of this collaborative study between the Royal College of General Practitioners Research and Surveillance Centre (RCGP RSC), University of Surrey and the National Physical Laboratory (NPL) is to develop a methodology to reconstruct missing or miscoded episode types. The data, gathered from the RCGP RSC network of over 230 practices, are analyzed and poor episode typing reconstructed by disease type. The methodology is tested in practices with good episode type data quality. This method could be used to improve prediction of epidemics, and to improve the quality of historical rates retrospectively.
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Head Neck Pathol
January 2025
Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.
We present the case of a 51-year-old man with Von Hippel-Lindau disease and a history of renal transplantation who developed a persistent, painful tongue lesion with episodes of significant swelling. Given his history of prolonged immunosuppression and elevated cancer risk, oral squamous cell carcinoma was a major concern. However, histopathological evaluation confirmed recrudescent herpes simplex virus (HSV) infection rather than malignancy.
View Article and Find Full Text PDFPathogens
December 2024
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya 07070, Türkiye.
The number of older adults undergoing organ transplantation, and waiting lists are increasing. The epidemiological data on infections in older transplant patients are scarce. The objective of the study was to investigate the incidence and distribution of infectious complications in older patients according to post-transplant periods.
View Article and Find Full Text PDFCureus
December 2024
Department of Osteopathic Manipulative Medicine, Liberty University College of Osteopathic Medicine, Lynchburg, USA.
An 88-year-old male with a history of cervical spondylosis (status post laminectomy of C2-C3 and laminoplasty of C4-C5), chronic congestive heart failure (CHF), pulmonary embolism, and lumbar spinal stenosis presented to an outpatient sports medicine clinic with neck pain following a fall five days prior due to loss of balance. He reported pain on the left side worsened by movement and accompanied by neck "clicking." A physical exam showed severe limitation in cervical spine extension limited by pain and loss of lordotic curve and a neurologic exam demonstrated weakness in the left leg secondary to a previous back surgery.
View Article and Find Full Text PDFSyst Rev
January 2025
Centre for Clinical Intervention Research, Copenhagen Trial Unit, Capital Region of Denmark, Copenhagen, Denmark.
Background: Type 1 diabetes is a serious, chronic disorder with an increasing incidence among children and adolescents. Glycemic control in individuals with type 1 diabetes is better managed through a basal-bolus regimen with either regular human or rapid-acting insulin analogues administered as a bolus at mealtimes. Rapid-acting insulin analogues have been hypothesized to cause optimal glycemic control and less risk of hypoglycemic episodes compared to regular human insulins.
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Medical Research Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway
Objectives: The objective of this study was to assess the quality of ECG recordings and the concordance between the automatic detection of cardiac arrhythmia episodes by a patch ECG and an insertable cardiac monitor.
Design: Prospective cohort study.
Setting And Participants: Endurance athletes diagnosed with paroxysmal atrial fibrillation (AF) and no other relevant comorbidities participating in a randomised controlled trial on the effects of training adaption.
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